Transgender cancer risk

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Diagnosis of prolactinoma in two male-to-female transsexual subjects following high-dose cross-sex hormone therapy. From the epidemiology perspective, the current review offers limited information about the risk and prognosis of cancer among transgender people. Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Risk factors for VTE found in a study by Gooren et al of 2, transgender women included smoking, immobilization due to gender confirmation surgery, and presence of a hypercoagulable disorder. In the United States, efforts are underway to assemble a cohort of transgender people enrolled in integrated health-care delivery systems Female sex hormones may also play a role in the pathogenesis of meningiomas.

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None of the 3 cases had hormone prescriptions from the VA.

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Cancer in Transgender People: Evidence and Methodological Considerations

Carcinoma of breast in trans-sexual individuals after surgical and hormonal interference with the primary and secondary sex characteristics. Published online May 9. It is also important to acknowledge that transgender people represent a heterogeneous population group. Transgender people comprise a diverse group of individuals whose gender identity or expression differs from that originally assigned to them at birth. Prolactinomas are the most common pituitary tumors that tend to be relatively small, slow growing, and diagnosed predominantly in women 86 Physical aspects of transgender endocrine therapy. Exogenous estrogen binds to the estrogen receptor in the breast tissue and is hypothesized to stimulate carcinogenesis via increased cell proliferation, decreased apoptosis, and elevated production of oxidative metabolites that result in DNA damage 76

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Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology. Cancer Site or Tumor Type No. Can Patients Find You? Although most reported cases of prostate cancer in transwomen presented with high prostate-specific antigen PSA levels, a feature of more aggressive disease, it should be kept in mind that almost all of these cases were symptomatic or at least had a palpable prostate lesion at diagnosis. In the second cross-sectional studytranswomen and transmen who had at least 3 months of cross-sex hormone therapy between and were each age matched to 6 controls, 3 nontransgender males and 3 nontransgender females.

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